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Experience with intracavernosal tri-mixture for the management of neurogenic erectile dysfunction.

Authors :
Chao R
Clowers DE
Source :
Archives of physical medicine and rehabilitation [Arch Phys Med Rehabil] 1994 Mar; Vol. 75 (3), pp. 276-8.
Publication Year :
1994

Abstract

Using papaverine, papaverine/phentolamine, or prostaglandin E1 (PGE1), intracavernosal pharmacotherapy has been successful in treating erectile dysfunction. The limiting factor of using these medicines is intracorporeal fibrosis with the first two and a high cost with PGE1. Our experience with intracavernosal therapy in patients with impotence secondary to neurogenic disease has included 35 men, 30 of whom are spinal cord injured, 3 after radical prostatectomy, 1 with multiple sclerosis, and 1 with lower extremity weakness after surgery. Patients ranged in age from 22 to 59 years, with an average of 36.3 years; mean follow-up was 13.8 months. Intracavernosal therapy has been performed with a tri-mixture of papaverine hydrochloride (smooth muscle relaxant), phentolamine mesylate (alpha-adrenergic blocking agent) and alprostadil (PGE1- a vasodilator and smooth muscle relaxant). Of the patient population, all 35 patients were able to have adequate erections for sexual relations with minimal complications. Acting synergistically, the ingredients promote erectile activity using small doses and without a significant incidence of priapism or fibrosis. Techniques of injection, dosing and followup are discussed.

Details

Language :
English
ISSN :
0003-9993
Volume :
75
Issue :
3
Database :
MEDLINE
Journal :
Archives of physical medicine and rehabilitation
Publication Type :
Academic Journal
Accession number :
8129578
Full Text :
https://doi.org/10.1016/0003-9993(94)90028-0