Back to Search
Start Over
Experience with intracavernosal tri-mixture for the management of neurogenic erectile dysfunction.
- Source :
-
Archives of physical medicine and rehabilitation [Arch Phys Med Rehabil] 1994 Mar; Vol. 75 (3), pp. 276-8. - Publication Year :
- 1994
-
Abstract
- Using papaverine, papaverine/phentolamine, or prostaglandin E1 (PGE1), intracavernosal pharmacotherapy has been successful in treating erectile dysfunction. The limiting factor of using these medicines is intracorporeal fibrosis with the first two and a high cost with PGE1. Our experience with intracavernosal therapy in patients with impotence secondary to neurogenic disease has included 35 men, 30 of whom are spinal cord injured, 3 after radical prostatectomy, 1 with multiple sclerosis, and 1 with lower extremity weakness after surgery. Patients ranged in age from 22 to 59 years, with an average of 36.3 years; mean follow-up was 13.8 months. Intracavernosal therapy has been performed with a tri-mixture of papaverine hydrochloride (smooth muscle relaxant), phentolamine mesylate (alpha-adrenergic blocking agent) and alprostadil (PGE1- a vasodilator and smooth muscle relaxant). Of the patient population, all 35 patients were able to have adequate erections for sexual relations with minimal complications. Acting synergistically, the ingredients promote erectile activity using small doses and without a significant incidence of priapism or fibrosis. Techniques of injection, dosing and followup are discussed.
- Subjects :
- Adult
Alprostadil economics
Alprostadil pharmacology
Cost-Benefit Analysis
Drug Combinations
Drug Costs
Drug Monitoring
Drug Synergism
Erectile Dysfunction etiology
Erectile Dysfunction physiopathology
Fibrosis
Follow-Up Studies
Humans
Injections
Male
Middle Aged
Papaverine economics
Papaverine pharmacology
Patient Satisfaction
Penile Diseases chemically induced
Penile Diseases pathology
Phentolamine economics
Phentolamine pharmacology
Priapism chemically induced
Alprostadil therapeutic use
Erectile Dysfunction drug therapy
Multiple Sclerosis complications
Papaverine therapeutic use
Penile Erection drug effects
Phentolamine therapeutic use
Prostatectomy adverse effects
Spinal Cord Injuries complications
Subjects
Details
- Language :
- English
- ISSN :
- 0003-9993
- Volume :
- 75
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Archives of physical medicine and rehabilitation
- Publication Type :
- Academic Journal
- Accession number :
- 8129578
- Full Text :
- https://doi.org/10.1016/0003-9993(94)90028-0