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A peptide-model for the heparin-binding property of pseudorabies virus glycoprotein III.
- Source :
-
Medical microbiology and immunology [Med Microbiol Immunol] 1993 Dec; Vol. 182 (6), pp. 285-92. - Publication Year :
- 1993
-
Abstract
- The pseudorabies virus glycoprotein III (PrV-gIII) has been identified previously as the major viral component binding to a heparin-like receptor on the surface of target cells. The amino acid sequence of gIII contains three regions corresponding to consensus sequences for heparin binding. A synthetic peptide corresponding to amino acids 134 to 141 of PrV-gIII bound heparin in a dot blot assay. In contrast, a synthetic peptide derived from amino acids 290-299 of PrV-gIII did not bind heparin. We therefore conclude that the region containing amino acid 134-141 is involved in binding to the heparin-like cellular receptor.
- Subjects :
- Amino Acid Sequence
Animals
Antithrombin III pharmacology
Binding Sites drug effects
Cell Line
Cells, Cultured
Consensus Sequence
Herpesvirus 1, Suid chemistry
Immunoblotting
Models, Chemical
Molecular Sequence Data
Oligopeptides chemical synthesis
Receptors, Cell Surface metabolism
Viral Envelope Proteins chemical synthesis
Heparin metabolism
Herpesvirus 1, Suid metabolism
Oligopeptides metabolism
Viral Envelope Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0300-8584
- Volume :
- 182
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Medical microbiology and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 8121329
- Full Text :
- https://doi.org/10.1007/BF00191944