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[The effect of calcium-regulating pharmacological preparations on the formation of a generator of pathologically enhanced excitation in the system of the dorsal horns of the spinal cord].
- Source :
-
Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1993 Sep; Vol. 116 (9), pp. 288-90. - Publication Year :
- 1993
-
Abstract
- A model of spinal pain syndrome induced by a generator of abnormally increased excitation in the system of dorsal horns of the spinal cord with penicillin was used to test the calcium channel blockers OF5015 and nimotop, as well as calcium gluconate for their effects. The drugs were administered orally, intraperitoneally, intracisternally and applied to the spinal cord in combination with penicillin which was used to induce the pain syndrome. The action of the agents were compared with that of analgin. OF5015 given in a dose orally was shown to attenuate the pain syndrome to a greater extent than analgin. Nimotop and calcium gluconate given orally or intrasystematically failed to affect the pain syndrome. When applied to the spinal cord, all the drugs substantially attenuated the pain syndrome or prevented its development.
- Subjects :
- Acute Disease
Animals
Dipyrone therapeutic use
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Nimodipine therapeutic use
Organic Chemicals
Pain chemically induced
Penicillins
Rats
Calcium Channel Blockers therapeutic use
Calcium Gluconate therapeutic use
Pain drug therapy
Spinal Cord drug effects
Subjects
Details
- Language :
- Russian
- ISSN :
- 0365-9615
- Volume :
- 116
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Biulleten' eksperimental'noi biologii i meditsiny
- Publication Type :
- Academic Journal
- Accession number :
- 8118004