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Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus.
- Source :
-
Virology [Virology] 1994 Feb 15; Vol. 199 (1), pp. 132-40. - Publication Year :
- 1994
-
Abstract
- A plasmid vector, termed pSG5rab.gp, that expresses the rabies virus glycoprotein under the control of an SV40 early promoter, was tested in C3H/He mice for induction of rabies virus-specific immune responses. Mice immunized intramuscularly with the pSG5rab.gp vector developed rabies virus glycoprotein-specific cytolytic T cells, lymphokine-secreting T helper cells of the TH1 subset, and rabies virus-neutralizing antibodies. Mice vaccinated with the pSG5rab.gp vector were fully protected against a subsequent challenge with rabies virus.
- Subjects :
- Animals
Antigens, Viral genetics
Antigens, Viral immunology
B-Lymphocytes immunology
Cell Line
Cricetinae
Female
Genetic Vectors
Glycoproteins immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Plasmids immunology
Rabies Vaccines immunology
Rabies virus immunology
T-Lymphocytes immunology
Transfection
Viral Envelope Proteins immunology
Glycoproteins genetics
Plasmids genetics
Rabies prevention & control
Rabies Vaccines genetics
Rabies virus genetics
Viral Envelope Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0042-6822
- Volume :
- 199
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 8116236
- Full Text :
- https://doi.org/10.1006/viro.1994.1105