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Proton spectroscopy of the brain in HIV infection: correlation with clinical, immunologic, and MR imaging findings.
- Source :
-
Radiology [Radiology] 1993 Jul; Vol. 188 (1), pp. 119-24. - Publication Year :
- 1993
-
Abstract
- Abnormalities at cerebral proton spectroscopy occur in patients with the acquired immunodeficiency syndrome (AIDS). N-acetyl aspartate (NAA) is believed to be a neuronal marker, and neuronal loss is thought to underlie the human immunodeficiency virus (HIV)-associated cognitive/motor complex. The proton spectra in 103 HIV-seropositive patients and 23 control subjects were compared and correlated with clinical, immunologic, and radiologic measures of HIV infection. Significant (P < .05) reductions in the mean NAA/choline (Cho) and NAA/creatine (Cr) ratios were seen in patients with immune suppression and neurologic signs. Significant increases in the Cho/Cr ratios were seen in patients with low CD4 lymphocyte counts and abnormal magnetic resonance (MR) images. Reduced NAA ratios correlated with diffuse but not focal MR imaging abnormalities. Combined MR imaging and spectroscopy provides closer relationships to clinical and immunologic measures of disease than either modality alone. Spectroscopy is an adjunct to MR imaging and augments the value of an MR imaging study.
- Subjects :
- Adult
Aspartic Acid analogs & derivatives
Aspartic Acid metabolism
Brain metabolism
CD4-Positive T-Lymphocytes
Choline metabolism
Creatine metabolism
Female
HIV Infections immunology
HIV Infections metabolism
Humans
Leukocyte Count
Male
Middle Aged
Brain pathology
HIV Infections diagnosis
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Subjects
Details
- Language :
- English
- ISSN :
- 0033-8419
- Volume :
- 188
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 8099750
- Full Text :
- https://doi.org/10.1148/radiology.188.1.8099750