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Modulating effects of the synthetic thymic dipeptide pidotimod on the immune system in the aging rat.

Authors :
Chiarenza A
Iurato MP
Barbera N
Lempereur L
Cantarella G
Scapagnini U
Bernardini R
Source :
Pharmacology & toxicology [Pharmacol Toxicol] 1994 Apr-May; Vol. 74 (4-5), pp. 262-6.
Publication Year :
1994

Abstract

We have investigated the in vivo and in vitro effect of pidotimod, a synthetic thymic-derived drug, on the immune response in young (2 month-old), and aging (24 month-old) Sprague-Dawley rats. We studied the effect of different doses of pidotimod on the responsiveness of both cultured peripheral blood lymphocytes and splenocytes to mitogenic stimuli, as well as on interleukin-2 production by peripheral blood lymphocytes after stimulation with interleukin-1 and phytohemagglutinin. Treatment with pidotimod in vivo as well as in vitro resulted in an increase of tritiated thymidine incorporation in both mitogen-stimulated lymphocytes and splenocytes from 24 month-old rats. Production of IL-2 from lymphocytes of 24 month-old rats was significantly increased in groups of animals treated with pidotimod. On the other hand, treatment with pidotimod did not influence the responsiveness of 2 month-old rat lymphocytes to mitogens, nor affected IL-2 production. Our results suggest a possible specific modulatory activity of pidotimod on the aging immune system.

Details

Language :
English
ISSN :
0901-9928
Volume :
74
Issue :
4-5
Database :
MEDLINE
Journal :
Pharmacology & toxicology
Publication Type :
Academic Journal
Accession number :
8090697
Full Text :
https://doi.org/10.1111/j.1600-0773.1994.tb01109.x