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Modulating effects of the synthetic thymic dipeptide pidotimod on the immune system in the aging rat.
- Source :
-
Pharmacology & toxicology [Pharmacol Toxicol] 1994 Apr-May; Vol. 74 (4-5), pp. 262-6. - Publication Year :
- 1994
-
Abstract
- We have investigated the in vivo and in vitro effect of pidotimod, a synthetic thymic-derived drug, on the immune response in young (2 month-old), and aging (24 month-old) Sprague-Dawley rats. We studied the effect of different doses of pidotimod on the responsiveness of both cultured peripheral blood lymphocytes and splenocytes to mitogenic stimuli, as well as on interleukin-2 production by peripheral blood lymphocytes after stimulation with interleukin-1 and phytohemagglutinin. Treatment with pidotimod in vivo as well as in vitro resulted in an increase of tritiated thymidine incorporation in both mitogen-stimulated lymphocytes and splenocytes from 24 month-old rats. Production of IL-2 from lymphocytes of 24 month-old rats was significantly increased in groups of animals treated with pidotimod. On the other hand, treatment with pidotimod did not influence the responsiveness of 2 month-old rat lymphocytes to mitogens, nor affected IL-2 production. Our results suggest a possible specific modulatory activity of pidotimod on the aging immune system.
- Subjects :
- Animals
Cells, Cultured
Immune System drug effects
Interleukin-2 biosynthesis
Lymphocyte Activation immunology
Lymphocytes immunology
Male
Pyrrolidonecarboxylic Acid pharmacology
Rats
Rats, Sprague-Dawley
Spleen immunology
Thiazolidines
Adjuvants, Immunologic pharmacology
Aging immunology
Pyrrolidonecarboxylic Acid analogs & derivatives
Thiazoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0901-9928
- Volume :
- 74
- Issue :
- 4-5
- Database :
- MEDLINE
- Journal :
- Pharmacology & toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 8090697
- Full Text :
- https://doi.org/10.1111/j.1600-0773.1994.tb01109.x