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Cloning of two novel ABC transporters mapping on human chromosome 9.
- Source :
-
Genomics [Genomics] 1994 May 01; Vol. 21 (1), pp. 150-9. - Publication Year :
- 1994
-
Abstract
- The family of ATP binding cassette (ABC) transporters or traffic ATPases is composed of several membrane-associated proteins that transport a great variety of solutes across cellular membranes. Two novel mammalian members of the family, ABC1 and ABC2, have been identified by a PCR-based approach. They belong to a group of traffic ATPases encoded as a single multifunctional protein, such as CFTR, STE 6, and P-glycoproteins. Their peculiar structural features and close relationship to ABC transporters involved in nodulation suggest that ABC1 and ABC2 define a novel subgroup of mammalian traffic ATPases.
- Subjects :
- ATP Binding Cassette Transporter 1
ATP-Binding Cassette Transporters classification
Adenosine Triphosphatases classification
Amino Acid Sequence
Animals
Base Sequence
Biological Transport, Active
Chromosome Mapping
Cloning, Molecular
Cricetinae
DNA, Complementary genetics
Gene Expression
Genes
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Sequence Alignment
Sequence Homology, Amino Acid
Tumor Cells, Cultured
ATP-Binding Cassette Transporters genetics
Adenosine Triphosphatases genetics
Chromosomes, Human, Pair 9
Membrane Proteins genetics
Multigene Family
Subjects
Details
- Language :
- English
- ISSN :
- 0888-7543
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Genomics
- Publication Type :
- Academic Journal
- Accession number :
- 8088782
- Full Text :
- https://doi.org/10.1006/geno.1994.1237