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[A case of congenital protein C deficiency with pulmonary thromboembolism].
- Source :
-
Nihon Kyobu Shikkan Gakkai zasshi [Nihon Kyobu Shikkan Gakkai Zasshi] 1994 May; Vol. 32 (5), pp. 497-501. - Publication Year :
- 1994
-
Abstract
- A 47-year-old woman, with a history of recurrent venous thrombosis in her lower limbs (1988 and June, 1992), was admitted because of pulmonary thromboembolism in the right middle lung lobe. She was given anti-coagulant therapy with warfarin. The consolidation in the right middle lobe disappeared within two months. Hematological examinations concerning the coagulation and fibrinolytic system showed a significant decrease in both the serum concentration and the activity of protein C, a vitamin K-dependent hepatic protein which acts as an anticoagulant by shutting off fibrin formation and stimulating fibrinolysis. Since a sister of the patient also has a history of venous thrombosis, several members of her family were tested for protein C deficiency. The familial study revealed that her sister and mother had both a decreased concentration and depressed activity of protein C, indicating that this is a case of congenital protein C deficiency. Warfarin therapy has been continued to reduce the prothrombin time to 70% of the normal control level, resulting in no further episodes of thrombosis.
Details
- Language :
- Japanese
- ISSN :
- 0301-1542
- Volume :
- 32
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Nihon Kyobu Shikkan Gakkai zasshi
- Publication Type :
- Academic Journal
- Accession number :
- 8084108