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Effect of transforming growth factor-beta 1 on plasminogen activators and plasminogen activator inhibitor-1 in renal glomerular cells.
- Source :
-
Experimental nephrology [Exp Nephrol] 1993 Nov-Dec; Vol. 1 (6), pp. 343-50. - Publication Year :
- 1993
-
Abstract
- Recent evidence suggests that the balance between serine proteases and their inhibitors is central to the maintenance of the glomerular extracellular matrix. We have characterised the urokinase type and the tissue type plasminogen activators (PA) and their inhibitor, PAI-1, secreted from glomerular epithelial and mesangial cells as well as their co-cultures and have investigated the effect of transforming growth factor-beta 1 (TGF-beta 1) on the production of such species. Similar data were derived from whole glomeruli suspensions. TGF-beta 1 increased PAI-1 production significantly in epithelial and mesangial cells as well as in whole glomeruli, while PA production was decreased; platelet-derived growth factor had no effect. These effects are consistent with a possible decrease in matrix proteolysis, suggesting a mechanism by which TGF-beta 1 may enhance mesangial matrix accumulation, a characteristic of many forms of glomerular disease.
- Subjects :
- Epithelial Cells
Epithelium metabolism
Humans
Kidney Glomerulus cytology
Plasminogen Activator Inhibitor 1 genetics
RNA, Messenger metabolism
Tissue Plasminogen Activator metabolism
Urokinase-Type Plasminogen Activator metabolism
Kidney Glomerulus metabolism
Plasminogen Activator Inhibitor 1 metabolism
Plasminogen Activators metabolism
Transforming Growth Factor beta pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1018-7782
- Volume :
- 1
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Experimental nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 8081986