Thymus influence on the conversion of 19S to 7S antibody formation in the response to TNP-Brucella.

Authors :: Romano TJ
Thorbecke GJ
Source :: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1975 Aug; Vol. 115 (2), pp. 332-4.
Publication Year :: 1975
Abstract: Serially transferred LAF spleen cells show a deficient 7S PFC response to TNP-Brucella when Tx as compared to normal irradiated intermediate hosts are used. This defect can be corrected by combining the spleen cells with lymph node cells from the Tx intermediate hosts. It is concluded that T helper cells, residing primarily in lymph node, are needed for efficient 19S leads to 7S conversion in the immune response.

Subjects :: Animals
Antibody-Producing Cells
Antigens, Bacterial
Immunologic Memory
Lymph Nodes immunology
Lymphocyte Transfusion
Male
Mice
Thymectomy
Thymus Gland radiation effects
Antibody Formation
Brucella abortus immunology
Immunoglobulin G
Immunoglobulin M
Nitrophenols immunology
Thymus Gland immunology

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