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Pneumocandin D0, a new antifungal agent and potent inhibitor of Pneumocystis carinii.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 1994 Jul; Vol. 47 (7), pp. 755-64. - Publication Year :
- 1994
-
Abstract
- Pneumocandin D0 (9), a new member of the echinocandin class of antifungal agents, has been isolated as a minor constituent from fermentation broths of the filamentous fungi Zalerion arboricola (ATCC 20957). The structure of 9 has been determined mainly on the basis of spectroscopic analysis and by comparison with published data for similar compounds. To date, pneumocandin D0 has been found to be the most potent inhibitor of Pneumocystis carinii development in vivo within the natural-occurring echinocandin family of antifungal agents.
- Subjects :
- Amino Acid Sequence
Animals
Anti-Bacterial Agents biosynthesis
Antifungal Agents biosynthesis
Candidiasis drug therapy
Echinocandins
Fermentation
Mice
Mice, Inbred Strains
Mitosporic Fungi metabolism
Molecular Sequence Data
Molecular Structure
Peptides, Cyclic biosynthesis
Peptides, Cyclic isolation & purification
Peptides, Cyclic pharmacology
Pneumonia, Pneumocystis drug therapy
Spectrometry, Mass, Fast Atom Bombardment
Anti-Bacterial Agents isolation & purification
Anti-Bacterial Agents pharmacology
Antifungal Agents isolation & purification
Antifungal Agents pharmacology
Peptides
Pneumocystis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8820
- Volume :
- 47
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 8071120
- Full Text :
- https://doi.org/10.7164/antibiotics.47.755