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Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve.
- Source :
-
Neuroscience letters [Neurosci Lett] 1994 Mar 14; Vol. 169 (1-2), pp. 181-4. - Publication Year :
- 1994
-
Abstract
- Membrane potential changes of rat neonatal optic nerves were studied in a sucrose-gap chamber. Nipecotic acid (NPA), which blocks uptake and promotes release of GABA, resulted in a bicuculline-sensitive depolarization (3.08 +/- 0.3 mV, n = 5). Pretreatment of the nerves with the anticonvulsant gabapentin (100 microM for 1 h) resulted in a near doubling of the NPA-induced depolarization (6.64 +/- 0.54 mV, n = 5). Gabapentin itself did not alter membrane potential, nor did brief applications of gabapentin enhance the NPA- or GABA-induced depolarization. Thus, gabapentin appears to enhance the releasable pool of GABA in this CNS neural system. These results have implications for the mechanism of the anticonvulsant properties of gabapentin.
- Subjects :
- Action Potentials drug effects
Animals
Bicuculline pharmacology
GABA-A Receptor Antagonists
Gabapentin
Membrane Potentials drug effects
Nipecotic Acids pharmacology
Rats
Rats, Wistar
Receptors, GABA-A drug effects
Receptors, GABA-A metabolism
Acetates pharmacology
Amines
Animals, Newborn metabolism
Anticonvulsants pharmacology
Cyclohexanecarboxylic Acids
Neuromuscular Depolarizing Agents pharmacology
Optic Nerve drug effects
Proline analogs & derivatives
gamma-Aminobutyric Acid pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 169
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 8047279
- Full Text :
- https://doi.org/10.1016/0304-3940(94)90386-7