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Transplantation studies of the role of the kidney in long-term blood pressure reduction following brief ACE inhibitor treatment in young spontaneously hypertensive rats.
- Source :
-
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 1994 Feb; Vol. 21 (2), pp. 129-31. - Publication Year :
- 1994
-
Abstract
- 1. Brief treatment with angiotensin-converting enzyme (ACE) inhibitors in young spontaneously hypertensive rats (SHR) causes a persistent reduction in blood pressure associated with a relatively selective reduction in renal vascular resistance. 2. To study the possible role of the kidney in this long-term hypotensive effect, we transplanted kidneys from untreated SHR into SHR that had been treated with perindopril (3 mg/kg per day) between 6 and 10 weeks of age and also transplanted kidneys from perindopril-pretreated SHR into untreated SHR. After transplantation, the remaining native kidney was removed so that only donor kidneys remained. 3. Untreated SHR that received kidneys from perindopril-pretreated SHR showed an initial fall in blood pressure followed by a rapid increase in pressure, weight loss and early death. 4. The transplantation of kidneys from control SHR into perindopril-pretreated SHR resulted in a rise in blood pressure that obviated the long-term reduction seen normally in these animals. 5. Kidneys from perindopril-pretreated SHR may be susceptible to the high blood pressure in untreated SHR. 6. The blood pressure increase in perindopril-pretreated SHR that accompanies substitution of the native kidneys by kidneys from untreated SHR further supports the hypothesis that the kidney is responsible for the long-term pressure effects following ACE inhibition in young SHR.
- Subjects :
- Aging physiology
Animals
Indoles pharmacology
Male
Nephrectomy
Perindopril
Rats
Rats, Inbred SHR
Renal Circulation drug effects
Vascular Resistance drug effects
Angiotensin-Converting Enzyme Inhibitors pharmacology
Blood Pressure drug effects
Kidney physiology
Kidney Transplantation physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0305-1870
- Volume :
- 21
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical and experimental pharmacology & physiology
- Publication Type :
- Academic Journal
- Accession number :
- 8039265
- Full Text :
- https://doi.org/10.1111/j.1440-1681.1994.tb02480.x