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Association between anti-human immunodeficiency virus type 1 (HIV-1) antibody-dependent cellular cytotoxicity antibody titers at birth and vertical transmission of HIV-1.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1994 Aug; Vol. 170 (2), pp. 308-12. - Publication Year :
- 1994
-
Abstract
- Because vertical transmission of human immunodeficiency virus type 1 (HIV-1) from mother to infant occurs in only 15%-35% of possible opportunities, natural immune defenses of the mother, fetus, or neonate may be protective against infection. The relation between antibody-dependent cellular cytotoxicity (ADCC) antibodies and HIV-1 infection was explored in 78 neonates born to HIV-infected women. More than 90% of sera had measurable ADCC titers against HIV-1IIIB. Infant titers were closely correlated with maternal titers but were independent of total IgG and total antibody reactive to the same strain in whole virus ELISA. At birth, mean ADCC antibody levels of infants or their mothers were the same for infants who were infected and those who ultimately seroreverted and remained healthy. ADCC antibody titers against HIV-1SF2 were weakly correlated with anti-HIV-1IIIB titers and did not predict protection from HIV-1 infection. High levels of anti-HIV-1 ADCC antibody at birth are not protective against vertical transmission of HIV-1.
- Subjects :
- Antiviral Agents therapeutic use
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Female
Fetal Blood immunology
HIV Infections drug therapy
HIV Infections immunology
Humans
Immunity, Maternally-Acquired
Infant, Newborn
Pregnancy
Prospective Studies
Retrospective Studies
Antibody-Dependent Cell Cytotoxicity
HIV Antibodies blood
HIV Infections transmission
HIV-1 immunology
Pregnancy Complications, Infectious drug therapy
Pregnancy Complications, Infectious immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 170
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 8035015
- Full Text :
- https://doi.org/10.1093/infdis/170.2.308