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A multicenter investigation of fixed-dose fluoxetine in the treatment of obsessive-compulsive disorder.
- Source :
-
Archives of general psychiatry [Arch Gen Psychiatry] 1994 Jul; Vol. 51 (7), pp. 559-67. - Publication Year :
- 1994
-
Abstract
- Objectives: To determine the effectiveness of fluoxetine hydrochloride at fixed doses of 20 mg/d, 40 mg/d, and 60 mg/d in patients with obsessive-compulsive disorder (OCD) and to evaluate its safety.<br />Methods: Fixed-dose fluoxetine hydrochloride (20 mg/d, 40 mg/d, 60 mg/d) was compared with placebo in two randomized, double-blind, parallel, 13-week trials of identical design in 355 outpatients with OCD aged 15 to 70 years (DSM-III-R criteria; 1 year's duration or longer; depression secondary if present).<br />Results: Fluoxetine (all doses) was significantly (P < or = .001) superior to placebo on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score (mean baseline-to-end-point decrease, 4.6, 5.5, and 6.5 vs 0.9, respectively, studies pooled) and other efficacy measures (P < or = .01). A trend suggesting greater efficacy at 60 mg/d was observed. Most patients (79.2%) completed the study. Eight adverse events were statistically significantly more frequent with fluoxetine and one, with placebo. For some events, incidence tended to increase with increasing dosage; however, few patients discontinued treatment for any single event.<br />Conclusion: Fluoxetine was associated with a statistically significant reduction in OCD severity, including time engaged in obsessional and/or compulsive behaviors. Adverse events infrequently led to study discontinuation.
- Subjects :
- Adolescent
Adult
Aged
Ambulatory Care
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Humans
Male
Middle Aged
Obsessive-Compulsive Disorder diagnosis
Obsessive-Compulsive Disorder psychology
Placebos
Psychiatric Status Rating Scales
Severity of Illness Index
Fluoxetine therapeutic use
Obsessive-Compulsive Disorder drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0003-990X
- Volume :
- 51
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Archives of general psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 8031229
- Full Text :
- https://doi.org/10.1001/archpsyc.1994.03950070051010