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Analysis of the nucleotide sequence of 48 kbp of the variola major virus strain India-1967 located on the right terminus of the conservative genome region.
- Source :
-
Virus research [Virus Res] 1994 Apr; Vol. 32 (1), pp. 37-55. - Publication Year :
- 1994
-
Abstract
- Computer analysis of a variola major virus (VAR) genomic fragment bounded by the open reading frames (ORFs) D1R and A33L, which is 47,961 bp long, revealed 46 potential ORFs. The VAR proteins were compared to the analogous proteins of vaccinia virus strain Copenhagen. The subunits of DNA-dependent RNA polymerase, as well as the transcription factors, mRNA-capping enzymes, and proteins necessary for the virion morphogenesis proved to be highly conservative within orthopoxviruses. The most pronounced differences between the VAR genome fragment under study and the corresponding vaccinia virus fragment were revealed in the vicinity of the gene encoding the A-type inclusion bodies protein. Possible functions of the analysed viral proteins are discussed.
- Subjects :
- Amino Acid Sequence
Base Sequence
DNA-Directed RNA Polymerases metabolism
Genes, Intracisternal A-Particle
Molecular Sequence Data
Morphogenesis
Open Reading Frames
RNA Caps metabolism
Sequence Alignment
Sequence Homology
Transcription Factors metabolism
Variola virus classification
Variola virus physiology
Viral Proteins metabolism
Virus Replication
DNA, Viral genetics
Genome, Viral
Variola virus genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0168-1702
- Volume :
- 32
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Virus research
- Publication Type :
- Academic Journal
- Accession number :
- 8030365
- Full Text :
- https://doi.org/10.1016/0168-1702(94)90060-4