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Refractory anaemia with hypereosinophilia and clonal abnormal metaphases detected only in the neutrophilic granulopoietic series.
- Source :
-
Acta haematologica [Acta Haematol] 1994; Vol. 91 (2), pp. 80-3. - Publication Year :
- 1994
-
Abstract
- We report a case with refractory anaemia terminating in an acute leukaemia, which showed from the very beginning an intense eosinophilia that lasted for the whole disease, and in which the eosinophilic metaphases, as documented by the 'Morphology, Antibody, Chromosome' technique, were normal. An unusual karyotypic anomaly in the setting of a myelodysplastic syndrome could only be detected in the neutrophilic series. A general approach to detect structural aberrations of specific human chromosomes in metaphase cells by chromosomal in situ suppression hybridization of DNA libraries from sorted human chromosomes has been applied for chromosomes 11, 3 and 2, in order to identify an extra copy of chromosome 2.
- Subjects :
- Acute Disease
Adult
Anemia, Refractory complications
Anemia, Refractory genetics
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 3
Clone Cells ultrastructure
DNA genetics
Fatal Outcome
Gene Library
Humans
Hypereosinophilic Syndrome complications
Hypereosinophilic Syndrome genetics
In Situ Hybridization
Karyotyping
Leukemia etiology
Male
Anemia, Refractory blood
Hypereosinophilic Syndrome blood
Metaphase
Neutrophils ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 0001-5792
- Volume :
- 91
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta haematologica
- Publication Type :
- Academic Journal
- Accession number :
- 8023649
- Full Text :
- https://doi.org/10.1159/000204259