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Inhibition by catechol and di(2-ethylhexyl)phthalate of pancreatic carcinogenesis after initiation with N-nitrosobis(2-hydroxypropyl)amine in Syrian hamsters.
- Source :
-
Carcinogenesis [Carcinogenesis] 1994 Jun; Vol. 15 (6), pp. 1193-6. - Publication Year :
- 1994
-
Abstract
- The effects of dietary administration of catechol (CC), paramethylcatechol (PMC) and di(2-ethylhexyl)phthalate (DEHP) were compared with that of butylated hydroxyanisole (BHA) in Syrian hamsters initiated with N-nitrosobis(2-hydroxypropyl)amine (BHP). Development of pancreatic atypical hyperplasias and adenocarcinomas in terms of combined multiplicity was significantly reduced by CC and DEHP. A similar slight but non-significant tendency was observed for BHA, while PMC was without effect. No statistically significant reduction of liver or gall bladder lesions was observed. The results thus suggest that both antioxidant and peroxisome proliferator categories of agents can inhibit pancreatic carcinogenesis in hamsters.
- Subjects :
- Animals
Body Weight drug effects
Cricetinae
Gallbladder pathology
Liver pathology
Male
Mesocricetus
Organ Size drug effects
Pancreas pathology
Pancreatic Neoplasms chemically induced
Pancreatic Neoplasms pathology
Carcinogens toxicity
Catechols therapeutic use
Diethylhexyl Phthalate therapeutic use
Nitrosamines toxicity
Pancreatic Neoplasms prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0143-3334
- Volume :
- 15
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 8020155
- Full Text :
- https://doi.org/10.1093/carcin/15.6.1193