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Regional distribution of 14C-zonisamide in rat brain.
- Source :
-
Epilepsy research [Epilepsy Res] 1994 Mar; Vol. 17 (3), pp. 233-6. - Publication Year :
- 1994
-
Abstract
- Zonisamide (1,2-benzisoxazole-3-methane sulfonamide) is a new antiepileptic drug developed in Japan. This compound was proven to possess a strong inhibitory effect on convulsions of cortical origin, whether induced by electric or chemical stimuli. Regional distribution of 14C-zonisamide was investigated in rat brain using autoradiography. A high uptake of 14C activity was observed in the cerebral cortex and the midbrain. A pair-match analysis of primary motor cortex versus primary sensory cortex revealed a slightly higher uptake in primary motor cortex. In the cerebellum, a higher uptake was observed in the cortex than medulla. Sagittal section analyses revealed that a high uptake of 14C activity was observed in the cerebral cortex and colliculus, and a moderate uptake was seen in the cerebellum, thalamus, hypothalamus, and striatal body, thus suggesting the distribution of 14C-zonisamide is similar to that of flunitrazepam and phenytoin.
Details
- Language :
- English
- ISSN :
- 0920-1211
- Volume :
- 17
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Epilepsy research
- Publication Type :
- Academic Journal
- Accession number :
- 8013445
- Full Text :
- https://doi.org/10.1016/0920-1211(94)90053-1