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Bladder defense mechanism.
- Source :
-
Transactions of the American Association of Genito-Urinary Surgeons [Trans Am Assoc Genitourin Surg] 1976; Vol. 68, pp. 83-6. - Publication Year :
- 1976
-
Abstract
- In order for micro-organisms to infect the urinary tract they must adhere to the vesical mucosa so that they remain after voiding. Experiments in our laboratory demonstrated that the bladder has a self-protective mechanism capable of preventing bacterial adherence to the surface. Histochemical staining demonstrated that this substance is a mucopolysaccharide. Treatment of the mucosa with acid disrupted the protective layer and resulted in a 20 to 100-fold increase in bacterial adherence. Within 24 hours this layer reappeared and binding was again reduced to normal. This phenomenon was not related to microbial species or metabolic activity.
- Subjects :
- Adhesiveness
Animals
Escherichia coli isolation & purification
Hydrochloric Acid pharmacology
Klebsiella pneumoniae isolation & purification
Male
Mucous Membrane microbiology
Rabbits
Staphylococcus aureus isolation & purification
Urinary Bladder cytology
Urinary Bladder microbiology
Bacterial Infections immunology
Urinary Bladder immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0065-7204
- Volume :
- 68
- Database :
- MEDLINE
- Journal :
- Transactions of the American Association of Genito-Urinary Surgeons
- Publication Type :
- Academic Journal
- Accession number :
- 801214