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Unbiased transmission of mutant alleles at the human retinoblastoma locus.
- Source :
-
Human genetics [Hum Genet] 1994 Jun; Vol. 93 (6), pp. 629-34. - Publication Year :
- 1994
-
Abstract
- The preferential transmission of the mutant allele to offspring from fathers who carry a germline mutation in the retinoblastoma gene was examined by analyzing 46 consecutive pedigrees. Among 75 offspring from 29 fathers, the ratio of carriers to noncarriers was 49%. Among the 106 offspring from 55 mothers the ratio was 57%. Neither ratio differs statistically from the expected 50%. When the analysis was limited to only those families with low-penetrance retinoblastoma, we still did not observe a biased transmission of alleles from fathers, although mothers did have an excess of carrier offspring of borderline statistical significance (the P-value was approximately 0.03). While we cannot rule out a biased transmission of alleles from some parents, there appears to be no such bias overall.
Details
- Language :
- English
- ISSN :
- 0340-6717
- Volume :
- 93
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Human genetics
- Publication Type :
- Academic Journal
- Accession number :
- 8005586
- Full Text :
- https://doi.org/10.1007/BF00201561