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Recombinant alpha-2B interferon treatment for childhood T--lymphoblastic disease in relapse. A Pediatric Oncology Group Phase II study.
Recombinant alpha-2B interferon treatment for childhood T--lymphoblastic disease in relapse. A Pediatric Oncology Group Phase II study.
- Source :
-
Cancer [Cancer] 1994 Jul 01; Vol. 74 (1), pp. 197-202. - Publication Year :
- 1994
-
Abstract
- Background: Children with chemotherapy refractory T-cell lymphoblastic leukemia/lymphoma were given alpha-interferon (alpha-IFN) to evaluate the efficacy and toxicity of this biologic response modifier.<br />Methods: Twenty children with T-cell acute lymphoblastic leukemia (T-cell ALL) in marrow relapse and one patient with mediastinal recurrence of T-cell non-Hodgkin's lymphoma (T-cell NHL) were enrolled. All patients had failed at least two previous multiagent drug trials. Recombinant alpha-IFN was given at 30 million U/M2/dose intravenously or subcutaneously for 10 doses over 14 days, followed by 3 doses per week until disease progression occurred.<br />Results: One child had a complete response (< 5% blasts) and three patients a partial response (5-25% blasts) in their bone marrow. All patients eventually showed signs of progressive disease. Significant toxicities included cardiac hypofunction in two patients and profound lethargy in two patients.<br />Conclusions: alpha-IFN is tolerated in children with T-cell ALL and T-cell NHL and has activity against chemotherapy resistant disease.
- Subjects :
- Adolescent
Child
Child, Preschool
Drug Administration Schedule
Female
Heart Failure etiology
Humans
Interferon alpha-2
Interferon-alpha administration & dosage
Interferon-alpha adverse effects
Male
Recombinant Proteins
Recurrence
Remission Induction
United States
Interferon-alpha therapeutic use
Leukemia-Lymphoma, Adult T-Cell therapy
Lymphoma, T-Cell therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0008-543X
- Volume :
- 74
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 8004576
- Full Text :
- https://doi.org/10.1002/1097-0142(19940701)74:1<197::aid-cncr2820740131>3.0.co;2-9