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Acrodermatitis chronica atrophicans: a case report and review of the literature.

Authors :
Leslie TA
Levell NJ
Cutler SJ
Cann KJ
Smith ME
Wright DJ
Gilkes JJ
Robinson TW
Source :
The British journal of dermatology [Br J Dermatol] 1994 Nov; Vol. 131 (5), pp. 687-93.
Publication Year :
1994

Abstract

We report a 55-year-old woman with acrodermatitis chronica atrophicans (ACA) and a peripheral sensory neuropathy. ACA is an uncommon late cutaneous manifestation of Lyme disease, which follows disseminated Borrelia burgdorferi infection. This is the second published case from the U.K. since serological diagnosis has been available. In this patient the diagnosis was confirmed by serology using a sensitive enzyme-linked immunosorbent assay and immunoblotting techniques. B. burgdorferi DNA was demonstrated in the affected skin using the polymerase chain reaction, although staining and cultures for the organism were negative. Recommended treatment of ACA is with oral doxycycline 100 mg twice daily for 28 days, but our patient did not respond well to this regimen. She was therefore treated with ceftriaxone intravenously for 21 days, which resulted in a rapid symptomatic and clinical response.

Details

Language :
English
ISSN :
0007-0963
Volume :
131
Issue :
5
Database :
MEDLINE
Journal :
The British journal of dermatology
Publication Type :
Academic Journal
Accession number :
7999602
Full Text :
https://doi.org/10.1111/j.1365-2133.1994.tb04984.x