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The nucleotide and deduced amino-acid sequences of a cDNA encoding lactate dehydrogenase from Caenorhabditis elegans: the evolutionary relationships of lactate dehydrogenases from mammals, birds, amphibian, fish, nematode, plants, bacteria, mycoplasma, and plasmodium.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1994 Nov 30; Vol. 205 (1), pp. 558-64. - Publication Year :
- 1994
-
Abstract
- The nucleotide and deduced amino-acid sequences of a cDNA encoding L-lactate dehydrogenase (LDH) from nematode, Caenorhabditis elegans, were reported. This first invertebrate LDH sequence of 333 amino acids, including the initiation methionine, exhibits 63% identity with that of the most primitive vertebrate lamprey. The evolutionary relationships among 36 LDH isozymes from mammals, birds, amphibian, fish, nematode, plants, bacteria, mycoplasma and plasmodium were analyzed. The invertebrate nematode LDH is evolutionarily positioned between plant LDH and mammalian testicular LDH-C isozymes. The mammalian LDH-C isozyme appears to have arisen after the invertebrate LDH, but prior to the divergence of vertebrate LDH-A (muscle) and LDH-B (heart) isozymes as described previously.
- Subjects :
- Amino Acid Sequence
Animals
Bacteria enzymology
Base Sequence
DNA
DNA, Complementary
Humans
Molecular Sequence Data
Mycoplasma enzymology
Plants enzymology
Plasmodium enzymology
Sequence Alignment
Species Specificity
Biological Evolution
Caenorhabditis elegans enzymology
L-Lactate Dehydrogenase genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 205
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 7999079
- Full Text :
- https://doi.org/10.1006/bbrc.1994.2701