Back to Search
Start Over
Preoperative myocardial cell damage in patients with unstable angina undergoing coronary artery bypass graft surgery.
Preoperative myocardial cell damage in patients with unstable angina undergoing coronary artery bypass graft surgery.
- Source :
-
Anesthesiology [Anesthesiology] 1994 Dec; Vol. 81 (6), pp. 1324-31. - Publication Year :
- 1994
-
Abstract
- Background: Troponin-T is one of the contractile proteins of the myocardium. Its release into the circulation indicates various degrees of myocardial cell damage. Troponin-T may be measured in serum with a recently developed enzyme immunoassay. This immunoassay was used to evaluate the preoperative myocardial cell damage in patients with stable and unstable angina undergoing elective coronary artery bypass graft surgery, and it was compared with conventional assays of creatine kinase (CK) MB isoenzyme activity and mass.<br />Methods: Twenty-one patients with unstable angina and 31 with stable angina were studied. Troponin-T, CK-MB activity, and CK-MB mass were measured 24 h before anesthesia and surgery, immediately before induction of anesthesia, before and after cardiopulmonary bypass, at the end of surgery, and 24 h afterward.<br />Results: In 90% (19 of 21) of the patients with unstable angina, troponin-T was increased 24 h before anesthesia (median 0.33 microgram/l, range 0.15-5.2 micrograms/l), whereas only 3% (1 of 31) of the patients with stable angina had increased values (median 0.0 microgram/l, range 0.0-0.53 microgram/l). The difference was statistically significant (P < 0.001). The same profile was found in patients with and without unstable angina immediately before induction of anesthesia (86% [18 of 21] and 0%, respectively) and before cardiopulmonary bypass (62% [13 of 21] and 0%, respectively). In contrast to troponin-T, CK-MB activity was increased in only 0-14% of patients with unstable angina, and CK-MB mass was increased in only 9-24%. After bypass troponin-T increased in both groups (P < 0.01), but there was no longer a statistically significant difference between the groups. Twelve percent (4 of 31) of the patients in the stable angina group and 28% (6 of 21) in the unstable group had major cardiac events (P not significant).<br />Conclusions: The study data suggest that many patients with unstable angina undergoing elective coronary artery bypass graft surgery have already increased troponin-T levels preoperatively, although conventional biochemical markers such as CK-MB activity and mass are at a normal range. Increased troponin-T and normal CK-MB concentrations may reflect some degree of ischemic myocardial cell damage. Because of the small number of patients in the study, the influence of preoperative myocardial injury on perioperative outcome could not be clarified.
- Subjects :
- Adult
Aged
Angina, Unstable enzymology
Angina, Unstable pathology
Biomarkers
Creatine Kinase metabolism
Electrocardiography
Enzyme-Linked Immunosorbent Assay
Female
Humans
Isoenzymes
Isoflurane
Male
Middle Aged
Myocardial Infarction diagnosis
Preanesthetic Medication
Preoperative Care
Prognosis
Troponin T
Angina, Unstable blood
Coronary Artery Bypass
Intraoperative Complications diagnosis
Myocardium pathology
Troponin blood
Subjects
Details
- Language :
- English
- ISSN :
- 0003-3022
- Volume :
- 81
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Anesthesiology
- Publication Type :
- Academic Journal
- Accession number :
- 7992899
- Full Text :
- https://doi.org/10.1097/00000542-199412000-00005