Interaction of some anti-hypoxia drugs with hydroxypropyl-beta-cyclodextrin studied by means of charge transfer chromatography.

The interaction of 12 anti-hypoxia drugs with hydroxypropyl-beta-cyclodextrin (HPBCD) and the influence of LiCl, NaCl and KCl on the strength of interaction was studied by charge transfer chromatography. Most of the drugs form inclusion complexes with HPBCD and the relative strength of interaction varies markedly according to the structure of the drugs. Salts exert a considerable influence on the inclusion complex formation and the effect depends on the radii of the cation. The significant correlations between the lipophilicity of drugs and their capacity to form inclusion complexes with HPBCD indicate the involvement of hydrophobic forces in the interaction.