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Monoclonal antibodies against metalloporphyrins. Specificity of interaction with structurally different metalloporphyrins.
- Source :
-
FEBS letters [FEBS Lett] 1994 Dec 05; Vol. 355 (3), pp. 314-6. - Publication Year :
- 1994
-
Abstract
- Monoclonal antibodies against Pd-coproporphyrin I have been obtained. The antibody specificity for free as well as for conjugated Pd-coproporphyrin I is characterized. Affinity constants are estimated for 3 monoclonal antibodies effectively interacting with free Pd-coproporphyrin I. A comparative study on the binding of monoclonal antibodies with analogues and derivatives of Pd-coproporphyrin I has revealed that the antigen is mainly located inside the antibody paratope. The protein adjoins complementary to the metalloporphyrin in such a manner that antibodies obtained discern only isomer I, and to some degree, isomer III of coproporphyrin.
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 355
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 7988696
- Full Text :
- https://doi.org/10.1016/0014-5793(94)01221-0