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[Hyperlipidemia and glomerulosclerosis in nephropathies: clinicomorphological comparisons].
- Source :
-
Terapevticheskii arkhiv [Ter Arkh] 1994; Vol. 66 (7), pp. 73-6. - Publication Year :
- 1994
-
Abstract
- An extracellular matrix (collagens I, III, IV) was studied in the glomeruli of patients demonstrating glomerular low density lipoproteins (LDL) and free of them. These two patients' groups were not found significantly different by age, nephropathy duration, blood pressure, serum concentrations of creatinine, triglycerides, HDL cholesterol. The LDL deposit group differed by longer duration of the nephrotic syndrome, higher 24-h proteinuria, lower serum albumin levels, higher total cholesterol in the serum and the proportion VLDL and LDL cholesterol to HDL cholesterol. They had noninflammatory nephropathies more frequently, collagen IV accumulated in the glomerulus more actively, there appeared interstitial collagens I and III. The discussion concerns the role of hypercholesterolemia with the above proportion of cholesterols, its duration, a type of cells dictating mesangial proliferation, in the development of LDL-deposit-induced glomerulosclerosis.
- Subjects :
- Adolescent
Adult
Biopsy
Collagen metabolism
Extracellular Matrix metabolism
Female
Glomerulosclerosis, Focal Segmental metabolism
Humans
Hyperlipidemias metabolism
Immunohistochemistry
Kidney metabolism
Kidney pathology
Kidney Diseases metabolism
Lipoproteins, LDL metabolism
Male
Middle Aged
Glomerulosclerosis, Focal Segmental pathology
Hyperlipidemias pathology
Kidney Diseases pathology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0040-3660
- Volume :
- 66
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Terapevticheskii arkhiv
- Publication Type :
- Academic Journal
- Accession number :
- 7985138