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Systematic evaluation of the adrenocortical function in patients with paracoccidioidomycosis.
- Source :
-
Mycopathologia [Mycopathologia] 1994 Aug; Vol. 127 (2), pp. 89-93. - Publication Year :
- 1994
-
Abstract
- Limited cortisol response to ACTH stimulation has been documented in 22 to 48% of patients with paracoccidioidomycosis (PM). Different approaches to interpret the test and inadequate selection of patients preclude an accurate appraisal of the actual incidence of adrenal insufficiency in PM. Rapid cosyntropin (ACTH) stimulation tests were performed in 38 consecutive patients (9 with the localized and 29 with the disseminated form of PM) and 40 normal controls. Subnormal cortisol responses to ACTH (60 minutes post-ACTH values below 455 nmol/l, 95% confidence limits) were found in only 4 patients (14%) with disseminated PM. If a retrospective sample of 6 patients studied previously (in whom tests were indicated due to clinical suspicion of Addison's disease) were included, or if the absolute cortisol increment above baseline was used for interpretation, we would find figures closer to those previously reported (23 and 24%, respectively). These data reflect that non-systematic evaluation or selection of a substandard criterion to interpret the test overestimates the frequency of adrenocortical insufficiency in PM.
- Subjects :
- Adrenal Insufficiency etiology
Adrenocorticotropic Hormone pharmacology
Adult
Aged
Evaluation Studies as Topic
Female
Humans
Hydrocortisone blood
Male
Middle Aged
Paracoccidioidomycosis complications
Adrenal Cortex Function Tests methods
Adrenal Insufficiency metabolism
Paracoccidioidomycosis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0301-486X
- Volume :
- 127
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Mycopathologia
- Publication Type :
- Academic Journal
- Accession number :
- 7984218
- Full Text :
- https://doi.org/10.1007/BF01103064