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Immunization with anticardiolipin cofactor (beta-2-glycoprotein I) induces experimental antiphospholipid syndrome in naive mice.
- Source :
-
Journal of autoimmunity [J Autoimmun] 1994 Aug; Vol. 7 (4), pp. 441-55. - Publication Year :
- 1994
-
Abstract
- Beta-2-GPI is a 50 kDa glycoprotein which is known to be a serum co-factor, with a role in determining the binding of pathogenic anticardiolipin antibodies to phospholipids. Immunization of naive mice with beta-2-GPI resulted in elevated levels of antibodies directed against negatively charged phospholipids (cardiolipin, phosphotidylserine, phosphatidylinositol). The presence of increased titres of antiphospholipid antibodies in the sera of the mice was later followed by prolonged activated partial thromboplastin time (APTT), thrombocytopenia, and when the mice were mated, by a high percentage of fetal resorptions in the uterus. These data point to the ability of beta-2-GPI to induce pathogenic anti-cardiolipin antibodies following active immunization.
- Subjects :
- Animals
Antibodies, Antinuclear biosynthesis
Antibody Specificity
Autoantigens immunology
Blood Cell Count
Female
Fetal Resorption immunology
Lupus Coagulation Inhibitor immunology
Mice
Mice, Inbred BALB C
Mice, Inbred ICR
Partial Thromboplastin Time
Thrombocytopenia immunology
beta 2-Glycoprotein I
Antibodies, Antiphospholipid biosynthesis
Antiphospholipid Syndrome etiology
Autoimmune Diseases etiology
Disease Models, Animal
Glycoproteins immunology
Vaccination
Subjects
Details
- Language :
- English
- ISSN :
- 0896-8411
- Volume :
- 7
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of autoimmunity
- Publication Type :
- Academic Journal
- Accession number :
- 7980847
- Full Text :
- https://doi.org/10.1006/jaut.1994.1032