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DMP 323, a nonpeptide cyclic urea inhibitor of human immunodeficiency virus (HIV) protease, specifically and persistently blocks intracellular processing of HIV gag polyprotein.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1994 Jul; Vol. 38 (7), pp. 1635-40. - Publication Year :
- 1994
-
Abstract
- DMP 323, a C-2-symmetrical cyclic urea, is representative of a new class of inhibitors of human immunodeficiency virus protease. In this study, we correlate the potent antiviral activity of DMP 323 in acute infections with antiprotease activity assessed by monitoring the inhibition of the processing of viral gag precursor polyprotein from chronically infected lymphoid and monocytoid cell lines. Electron microscopic examination confirmed that the inhibition of gag processing was associated with the production of immature viral particles. Reduction of DMP 323 in the environment of unprocessed gag viral particles did not result in the resumption of gag processing for at least 72 h.
- Subjects :
- Azepines
Cells, Cultured
HIV-1 drug effects
HIV-1 ultrastructure
Humans
Microscopy, Electron
Protein Processing, Post-Translational drug effects
RNA, Viral metabolism
Urea pharmacology
Virus Replication drug effects
Gene Products, gag metabolism
HIV Protease Inhibitors pharmacology
HIV-1 enzymology
Urea analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 38
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 7979297
- Full Text :
- https://doi.org/10.1128/AAC.38.7.1635