Back to Search
Start Over
Comparison between felodipine and isosorbide mononitrate as adjunct to beta blockade in patients > 65 years of age with angina pectoris.
- Source :
-
The American journal of cardiology [Am J Cardiol] 1994 Dec 15; Vol. 74 (12), pp. 1201-6. - Publication Year :
- 1994
-
Abstract
- Coronary artery disease is an increasingly common medical problem in the elderly, and relatively few studies investigating drug therapy focus on this population. To assess the efficacy and safety of the calcium channel blocker, felodipine, and isosorbide mononitrate (ISMN), as adjunct to optimal beta-blocker therapy in elderly patients, a placebo-controlled, double-blind study was conducted in 46 patients, aged between 65 and 80 years, with documented stress-induced angina pectoris and myocardial ischemia. With use of a latin-square design, with 3 periods of 4 weeks each, exercise testing was performed after each period. Felodipine, 5 mg once daily, significantly improved both time to ischemic threshold and pain threshold (p = 0.02 and p = 0.003, respectively, vs placebo), and tended to increase total exercise time (p = 0.06 vs placebo). In contrast, ISMN, 20 mg twice daily, did not significantly affect these parameters. Comparison of the 2 active treatment arms showed that, overall, felodipine was more effective than ISMN, with a statistically significant difference for time to ischemic threshold (p = 0.02). With regard to safety, felodipine was also better tolerated than ISMN, which led to more patients discontinuing study medication with ISMN (p < 0.05 between ISMN and felodipine). It is concluded that in elderly patients who are treated with optimal beta blockade, felodipine, but not ISMN, leads to an additional significant reduction in ischemic parameters during exercise.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Aged
Cross-Over Studies
Delayed-Action Preparations
Double-Blind Method
Drug Therapy, Combination
Exercise Test drug effects
Felodipine adverse effects
Female
Humans
Isosorbide Dinitrate adverse effects
Isosorbide Dinitrate therapeutic use
Male
Myocardial Ischemia drug therapy
Prospective Studies
Treatment Outcome
Vasodilator Agents adverse effects
Adrenergic beta-Antagonists therapeutic use
Angina Pectoris drug therapy
Felodipine therapeutic use
Isosorbide Dinitrate analogs & derivatives
Vasodilator Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9149
- Volume :
- 74
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 7977090
- Full Text :
- https://doi.org/10.1016/0002-9149(94)90548-7