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Expression of thrombomodulin in astrocytomas of various malignancy and in gliotic and normal brains.
- Source :
-
Journal of neuro-oncology [J Neurooncol] 1994; Vol. 19 (2), pp. 155-60. - Publication Year :
- 1994
-
Abstract
- A total of 22 surgical specimens, 16 astrocytomas with various malignancy, 3 brains adjacent to tumor and 3 brains with non-neoplastic lesion, was investigated immunohistochemically for the expression of thrombomodulin (TM). This membrane protein is localized on the vascular endothelium of nearly every human tissue and plays a crucial role in the maintenance of antithrombotic property of the endothelial cells. Although the normal cerebral vessels were negative for TM, the tumor vessels were positive for TM. The increased expression of TM was, however, demonstrated not only in glioblastomas but also in low-grade astrocytomas. Furthermore, the vessels in the brains adjacent to tumor and gliotic brains were also positive for TM. Those observations suggested that the tendency of intratumoral bleeding, which is rather characteristic of glioblastomas, is not simply explained by the altered expression of vascular endothelial TM. In two cases of glioblastoma, not only the blood vessels but also the tumor cells were positive. Considering the mitogenic activity of thrombin, a ligand for TM, the increased expression of TM might be related to the tumor neovascularization and also the tumor growth.
- Subjects :
- Astrocytoma blood supply
Astrocytoma pathology
Blood Vessels metabolism
Brain pathology
Brain Neoplasms blood supply
Brain Neoplasms pathology
Endothelium, Vascular metabolism
Glioblastoma blood supply
Glioblastoma metabolism
Glioblastoma pathology
Humans
Immunohistochemistry
Astrocytoma metabolism
Brain metabolism
Brain Neoplasms metabolism
Gliosis metabolism
Thrombomodulin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0167-594X
- Volume :
- 19
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of neuro-oncology
- Publication Type :
- Academic Journal
- Accession number :
- 7964991
- Full Text :
- https://doi.org/10.1007/BF01306457