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Suppression of GABAB receptor function in rat neocortical slices by amiloride.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1994 Jul 21; Vol. 260 (1), pp. 73-7. - Publication Year :
- 1994
-
Abstract
- Interactions of amiloride with GABAB receptors have been examined using spontaneously discharging rat neocortical slices. These discharges were suppressed by the GABAB receptor agonist baclofen (10 microM), and were prevented by amiloride and its analogs 5-(N,N-dimethyl)-amiloride, 5-(N-methyl-N-isobutyl)-amiloride and benzamil, but not by triamterene (100-500 microM). Each of these also increased the spontaneous discharge rate and reduced the discharge amplitude. The action of amiloride and its analogs in preventing the action of baclofen, may involve allosteric modification of the receptor binding sites via guanine nucleotide-binding proteins, or an indirect effect through antagonism of co-activated adenosine A1 receptors.
- Subjects :
- Amiloride analogs & derivatives
Animals
Baclofen pharmacology
Cerebral Cortex drug effects
Culture Media
In Vitro Techniques
Magnesium physiology
Male
Rats
Rats, Sprague-Dawley
Sodium-Hydrogen Exchangers metabolism
Triamterene pharmacology
Amiloride pharmacology
Cerebral Cortex metabolism
GABA-B Receptor Antagonists
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 260
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 7957628
- Full Text :
- https://doi.org/10.1016/0014-2999(94)90011-6