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The effect of the gastrointestinal lipase inhibitor, orlistat, on serum lipids and lipoproteins in patients with primary hyperlipidaemia.
The effect of the gastrointestinal lipase inhibitor, orlistat, on serum lipids and lipoproteins in patients with primary hyperlipidaemia.
- Source :
-
European journal of clinical pharmacology [Eur J Clin Pharmacol] 1994; Vol. 46 (5), pp. 405-10. - Publication Year :
- 1994
-
Abstract
- The effect of orlistat, a nonabsorbed inhibitor of gastric and pancreatic lipases, was examined in patients with primary hyperlipidaemia (serum cholesterol > or = 6.2 mmol.l-1 and triglycerides < or = 5.0 mmol.l-1) not responsive to dietary change alone. In a multicentre, randomised, double-blind study, 103 men and 70 women received 30, 90, 180, or 360 mg or orlistat or placebo for 8 weeks. Total and low-density lipoprotein cholesterol levels were reduced by 4% and 5% with 30 mg orlistat, by 7% and 8% with 90 mg orlistat, by 7% and 7% with 180 mg orlistat and by 11% and 10% with 360 mg orlistat compared to placebo. High density lipoprotein cholesterol levels significantly decreased in the 360 mg orlistat group. Triglyceride levels significantly increased in the placebo group but not in the drug groups. Body weight decreased by 1.2 kg with 360 mg orlistat, despite a weight maintenance diet. Decreases in vitamin E and D levels occurred, although both vitamins remained within the normal range. Adverse effects from the gastrointestinal tract were frequent, but led to discontinuation of therapy in only seven patients. Orlistat is a new therapeutic drug for the treatment of hyperlipidaemia that may be particularly useful among overweight patients. Its potential place in therapy will await long-term studies. Vitamin supplementation should be considered during treatment.
- Subjects :
- Adult
Aged
Apolipoproteins metabolism
Body Weight physiology
Cholesterol, VLDL blood
Diet, Fat-Restricted
Digestive System drug effects
Dose-Response Relationship, Drug
Double-Blind Method
Female
Humans
Hyperlipidemias blood
Lactones adverse effects
Male
Middle Aged
Orlistat
Triglycerides blood
Vitamins blood
Digestive System enzymology
Hyperlipidemias drug therapy
Lactones therapeutic use
Lipase antagonists & inhibitors
Lipids blood
Lipoproteins blood
Subjects
Details
- Language :
- English
- ISSN :
- 0031-6970
- Volume :
- 46
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- European journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 7957533
- Full Text :
- https://doi.org/10.1007/BF00191901