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In vitro and in vivo activity of a recombinant toxin, OLX-209, which targets the erbB-2 oncoprotein.
- Source :
-
Advances in enzyme regulation [Adv Enzyme Regul] 1994; Vol. 34, pp. 119-28. - Publication Year :
- 1994
-
Abstract
- OLX-209 has readily measurable activity, is safe in experimental animals, and is efficacious in model systems. These results support the concept of OLX-209 and provide groundwork for further development of this oncoprotein targeted agent.
- Subjects :
- Animals
Antibodies
Breast Neoplasms chemistry
Drug Design
Evaluation Studies as Topic
Exotoxins genetics
Exotoxins pharmacology
Humans
Immunotoxins pharmacology
Immunotoxins toxicity
Mice
Mice, Nude
Neoplasms, Experimental drug therapy
Recombinant Fusion Proteins pharmacology
Recombinant Fusion Proteins toxicity
Recombinant Proteins pharmacology
Single-Chain Antibodies
Stomach Neoplasms drug therapy
Tumor Cells, Cultured
Pseudomonas aeruginosa Exotoxin A
ADP Ribose Transferases
Bacterial Toxins
Exotoxins administration & dosage
Immunotoxins administration & dosage
Receptor, ErbB-2 drug effects
Recombinant Fusion Proteins administration & dosage
Virulence Factors
Subjects
Details
- Language :
- English
- ISSN :
- 0065-2571
- Volume :
- 34
- Database :
- MEDLINE
- Journal :
- Advances in enzyme regulation
- Publication Type :
- Academic Journal
- Accession number :
- 7942269
- Full Text :
- https://doi.org/10.1016/0065-2571(94)90012-4