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Polio vaccines and the origin of AIDS.
- Source :
-
Medical hypotheses [Med Hypotheses] 1994 Jun; Vol. 42 (6), pp. 347-54. - Publication Year :
- 1994
-
Abstract
- Although mass vaccination programs have resulted in the eradication of a number of human infectious diseases, vaccine contamination has been a persistent concern. In particular, it is now known that the early polio vaccines were contaminated with at least one monkey virus, SV40. The transfer of monkey viruses to man via contaminated vaccines is particularly relevant to the acquired immunodeficiency syndrome (AIDS), since the causative agent of AIDS, human immunodeficiency virus (HIV), is thought to be derived from a simian precursor virus. Furthermore, human infection with this virus appears to be a relatively recent event. We hypothesize that the AIDS pandemic may have originated with a contaminated polio vaccine that was administered to inhabitants of Equatorial Africa from 1957 to 1959. The mechanism of evolution of HIV from this vaccine remains to be determined.
- Subjects :
- Accidents
Acquired Immunodeficiency Syndrome epidemiology
Acquired Immunodeficiency Syndrome history
Animals
Cells, Cultured microbiology
Cricetinae
Democratic Republic of the Congo epidemiology
HIV-1 isolation & purification
History, 20th Century
Humans
Macaca microbiology
Neoplasms, Experimental microbiology
Poliovirus Vaccine, Inactivated history
Poliovirus Vaccine, Oral adverse effects
Poliovirus Vaccine, Oral history
Simian Acquired Immunodeficiency Syndrome microbiology
Simian Immunodeficiency Virus isolation & purification
Simian virus 40 isolation & purification
Simian virus 40 pathogenicity
Zoonoses
Acquired Immunodeficiency Syndrome transmission
Chlorocebus aethiops microbiology
Disease Outbreaks
Drug Contamination
Poliovirus Vaccine, Inactivated adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0306-9877
- Volume :
- 42
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Medical hypotheses
- Publication Type :
- Academic Journal
- Accession number :
- 7935079
- Full Text :
- https://doi.org/10.1016/0306-9877(94)90151-1