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Protein tyrosine kinases and TNF alpha secretion in human monocytes.
- Source :
-
International journal of immunopharmacology [Int J Immunopharmacol] 1994 May-Jun; Vol. 16 (5-6), pp. 407-12. - Publication Year :
- 1994
-
Abstract
- The role of protein tyrosine kinases (PTK) in TNF alpha secretion by human monocytes was investigated in this report. We showed that an immunomodulator such as Nocardia lysozyme digest (NLD) and a particulate agonist, zymosan, stimulated an increase in tyrosine phosphorylation of several endogenous substrates including 53-56 kDa protein which was the predominant phosphoprotein. In addition, NLD and zymosan induced TNF alpha secretion which was impaired by a PTK inhibitor, tyrphostin. We suggest that a cascade of kinases including PTK is involved in NLD and zymosan signalling.
Details
- Language :
- English
- ISSN :
- 0192-0561
- Volume :
- 16
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- International journal of immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 7927986
- Full Text :
- https://doi.org/10.1016/0192-0561(94)90029-9