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Phage display of a human antibody against Clostridium tetani toxin.
- Source :
-
Gene [Gene] 1994 Oct 11; Vol. 148 (1), pp. 167-8. - Publication Year :
- 1994
-
Abstract
- 9F12, a human antibody capable of neutralising tetanus toxin in an animal model, has been expressed as a Fab fragment in a phagemid system. The nucleotide sequence for the variable domain of both chains has been determined and compared to germline sequences.
- Subjects :
- Amino Acid Sequence
Antibodies, Bacterial biosynthesis
Antibody Specificity
Bacteriophages
Base Sequence
Genetic Vectors
Humans
Immunoglobulin Fab Fragments biosynthesis
Immunoglobulin Heavy Chains biosynthesis
Immunoglobulin Heavy Chains genetics
Immunoglobulin Variable Region biosynthesis
Immunoglobulin Variable Region genetics
Immunoglobulin kappa-Chains biosynthesis
Immunoglobulin kappa-Chains genetics
Molecular Sequence Data
Neutralization Tests
Sequence Analysis, DNA
Sequence Homology, Nucleic Acid
Antibodies, Bacterial genetics
Immunoglobulin Fab Fragments genetics
Recombinant Fusion Proteins biosynthesis
Tetanus Toxin immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0378-1119
- Volume :
- 148
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Gene
- Publication Type :
- Academic Journal
- Accession number :
- 7926831
- Full Text :
- https://doi.org/10.1016/0378-1119(94)90252-6