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Insulin requirement for the antihyperglycaemic effect of metformin.
- Source :
-
British journal of pharmacology [Br J Pharmacol] 1994 Mar; Vol. 111 (3), pp. 793-6. - Publication Year :
- 1994
-
Abstract
- 1. Insulin-dependent diabetic BB/S rats with little or no endogenous insulin were used to determine whether insulin is required for the acute antihyperglycaemic effect of metformin (dimethylbiguanide). 2. Metformin (250 mg kg-1, intrajejunally) did not lower the hyperglycaemia in BB/S rats in the absence of exogenous insulin, but metformin increased by 69% (P < 0.05) the blood glucose-lowering effect of exogenous insulin. 3. Metformin (250 mg kg-1, intrajejunally) improved glucose disposal in rats with a normal insulin response to an intravenous glucose challenge. Plasma glucose disappearance was increased from 0.7 +/- 0.1 to 2.5 +/- 0.1% min-1 (P < 0.05). 3. When the insulin response to glucose was suppressed with somatostatin and diazoxide, metformin improved glucose disposal to a similar extent to that in rats with a normal insulin response. Plasma glucose disappearance was increased from 0.24 +/- 0.02 to 1.0 +/- 0.1% min-1 (P < 0.01). 5. The results indicate that insulin is required for the acute antihyperglycaemic effect of metformin, but the extent of this effect is not proportional to the prevailing insulin concentration.
- Subjects :
- Animals
Blood Glucose drug effects
Blood Glucose metabolism
Glucose administration & dosage
Glucose Tolerance Test
Hyperglycemia blood
Infusions, Intravenous
Injections, Intravenous
Male
Rats
Rats, Inbred BB
Rats, Wistar
Somatostatin pharmacology
Diabetes Mellitus, Type 1 blood
Diabetes Mellitus, Type 1 drug therapy
Hyperglycemia drug therapy
Insulin pharmacology
Insulin physiology
Metformin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1188
- Volume :
- 111
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- British journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 7912625
- Full Text :
- https://doi.org/10.1111/j.1476-5381.1994.tb14807.x