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Intrathecal IgG synthesis and albumin leakage are increased in subjects with HIV-1 neurologic disease.
- Source :
-
Journal of acquired immune deficiency syndromes [J Acquir Immune Defic Syndr (1988)] 1994 Mar; Vol. 7 (3), pp. 265-71. - Publication Year :
- 1994
-
Abstract
- We analyzed matched cerebrospinal fluid and blood samples from 139 subjects enrolled in a study of the effects of human immunodeficiency virus type 1 (HIV-1) on the nervous system. Mean total intrathecal IgG synthesis rate was significantly higher in subjects with HIV-1-related neurologic disease (NeuroPos) than in HIV-1-seropositive (HIV+) subjects without neurologic disease (NeuroNeg) or at-risk seronegative controls (SNC). Mean trans-blood-brain barrier (BBB) albumin leakage (AL) rate increased significantly across groups (SNC < NeuroNeg < NeuroPos). AL was significantly higher in subjects with absolute CD4 counts < 100/mm3 versus those with > or = 100 cells/mm3 and significantly higher in AIDS compared with asymptomatic HIV+. Elevated total intrathecal IgG synthesis rate could not be accounted for solely by the presence of a damaged BBB, because 79% of subjects with elevated IgG synthesis rates had a normal BBB as assessed by the AL formula. Furthermore, the Tourtellotte formula inherently corrects for BBB leakage. We confirmed, using state-of-the-art albumin and IgG determinations, that intrathecal IgG synthesis is prevalent in all stages of HIV-1 disease. In the absence of a CNS opportunistic infection or tumor, mean total intrathecal IgG synthesis rate and trans-BBB AL are significantly higher in subjects with clinical HIV-1 CNS disease than in neurologically normally HIV+ subjects.
- Subjects :
- Adult
Aged
Albumins cerebrospinal fluid
Blood-Brain Barrier
CD4-CD8 Ratio
CD4-Positive T-Lymphocytes
Cross-Sectional Studies
HIV Infections blood
HIV Seropositivity blood
HIV Seropositivity cerebrospinal fluid
Humans
Immunoglobulin G blood
Immunoglobulin G cerebrospinal fluid
Leukocyte Count
Male
Middle Aged
Nephelometry and Turbidimetry
Nervous System Diseases blood
Serum Albumin analysis
Albumins metabolism
HIV Infections cerebrospinal fluid
HIV-1
Immunoglobulin G biosynthesis
Nervous System Diseases cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 0894-9255
- Volume :
- 7
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of acquired immune deficiency syndromes
- Publication Type :
- Academic Journal
- Accession number :
- 7906304