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p53 mutation hotspot in radon-associated lung cancer.
- Source :
-
Lancet (London, England) [Lancet] 1994 Jan 08; Vol. 343 (8889), pp. 86-7. - Publication Year :
- 1994
-
Abstract
- Mutations in gene p53 are the most common defects in lung cancer and may be a pathway through which environmental carcinogens initiate cancer. We investigated p53 mutations in lung cancers from uranium miners with high radon exposure. 16 (31%) of 52 large-cell and squamous-cell cancers from miners contained the same AGG to ATG transversion at codon 249, including cancers from 3 or 5 miners who had never smoked. This specific mutation has been reported in only 1 of 241 published p53 mutations from lung cancers. The codon 249 mutation may be a marker for radon-induced lung cancer.
- Subjects :
- Case-Control Studies
Codon genetics
Exons genetics
Humans
Lung Neoplasms etiology
Mining
Neoplasms, Radiation-Induced etiology
Occupational Diseases etiology
Uranium
Genes, p53 radiation effects
Lung Neoplasms genetics
Mutation
Neoplasms, Radiation-Induced genetics
Occupational Diseases genetics
Radon adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0140-6736
- Volume :
- 343
- Issue :
- 8889
- Database :
- MEDLINE
- Journal :
- Lancet (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 7903781