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An HTLV-I carrier who developed CD4+ T-CLL expressed the IL-2 receptor beta chain alone without expressing the alpha chain.
- Source :
-
British journal of haematology [Br J Haematol] 1993 Sep; Vol. 85 (1), pp. 185-7. - Publication Year :
- 1993
-
Abstract
- We describe a case of T-chronic lymphocytic leukaemia (T-CLL) with monoclonal proliferation of CD3+4+8- T cell expressing the interleukin 2 receptor (IL-2R) beta chain without expressing the alpha chain. Southern blot analysis of T-cell receptor beta chain gene revealed rearranged bands. The serum antibody was positive against human T-cell lymphotropic virus type I (HTLV-1)-associated antigens, but monoclonal integration of proviral DNA was not detected in the leukaemic cells. In accordance with the expression of IL-2R beta chain, the leukaemic cells proliferated in response to exogenous IL-2 without prior stimulation. However, culture supernatants of these cells did not show IL-2 activity. Since the role of the IL-2R beta chain in freshly isolated cells from T-CLL patients is not well understood, detailed analysis of this case would give us valuable information on the role of IL-2/IL-2R system in the proliferation of the leukaemic T cells.
- Subjects :
- Aged
Blotting, Southern
Cell Division immunology
Female
Gene Expression physiology
Humans
Interleukin-2 immunology
Leukemia, Prolymphocytic, T-Cell complications
Leukemia, Prolymphocytic, T-Cell immunology
CD4-Positive T-Lymphocytes physiology
Carrier State
HTLV-I Infections complications
Leukemia, Prolymphocytic, T-Cell genetics
Receptors, Interleukin-2 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1048
- Volume :
- 85
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 7902734
- Full Text :
- https://doi.org/10.1111/j.1365-2141.1993.tb08666.x