The selective histamine H1-receptor agonist 2-(3-trifluoromethylphenyl)histamine increases waking in the rat.

Authors :: Monti JM
Jantos H
Leschke C
Elz S
Schunack W
Source :: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 1994 Dec; Vol. 4 (4), pp. 459-62.
Publication Year :: 1994
Abstract: The effects of the selective histamine H1-receptor agonist, 2-(3-trifluoromethylphenyl)histamine, were studied in rats implanted with electrodes for chronic sleep recordings. 2-(3-Trifluoromethylphenyl)histamine (80-120 micrograms) injected into the left lateral ventricle increased wakefulness, whereas slow wave sleep was reduced. Pretreatment with pyrilamine (2.0 mg/kg) prevented the effects of the H1-receptor agonist on wakefulness and slow wave sleep. Our results further support the involvement of histamine in the modulation of the waking state.

Subjects :: Animals
Dose-Response Relationship, Drug
Electrodes, Implanted
Histamine administration & dosage
Histamine pharmacology
Histamine Agonists administration & dosage
Injections, Intraventricular
Male
Pyrilamine pharmacology
Rats
Rats, Wistar
Sleep drug effects
Histamine analogs & derivatives
Histamine Agonists pharmacology
Wakefulness drug effects

Language :: English
ISSN :: 0924-977X
Volume :: 4
Issue :: 4
Database :: MEDLINE
Journal :: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Publication Type :: Academic Journal
Accession number :: 7894255
Full Text :: https://doi.org/10.1016/0924-977x(94)90293-3

Full Text Access

Tools