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Dysregulation of photic induction of Fos-related protein in the biological clock during experimental trypanosomiasis.
- Source :
-
Neuroscience letters [Neurosci Lett] 1994 Nov 21; Vol. 182 (1), pp. 104-6. - Publication Year :
- 1994
-
Abstract
- The mammalian suprachiasmatic nuclei of the hypothalamus (SCN) serve as pacemaker for circadian rhythms and the immediate-early gene c-fos is known to be induced by photic stimulation in the SCN of rodents. We studied the induction of Fos-related protein following a light pulse in rats infected with Trypanosoma brucei. This parasite causes in humans African sleeping sickness, a neuropsychiatric syndrome that involves changes of endogenous biological rhythms. Fos-like immunoreactivity after photic stimulation was dramatically reduced in the SCN of trypanosome- infected rats during the subjective night. These findings indicate that the photic entrainment of the biological clock may be altered during the infection.
- Subjects :
- Animals
Gene Expression Regulation radiation effects
Genes, fos
Male
Proto-Oncogene Proteins c-fos genetics
Rats
Rats, Sprague-Dawley
Suprachiasmatic Nucleus metabolism
Biological Clocks
Light
Proto-Oncogene Proteins c-fos metabolism
Trypanosomiasis metabolism
Trypanosomiasis physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 182
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 7891872
- Full Text :
- https://doi.org/10.1016/0304-3940(94)90217-8