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A novel skeletal drug delivery system using a self-setting calcium phosphate cement. 5. Drug release behavior from a heterogeneous drug-loaded cement containing an anticancer drug.
- Source :
-
Journal of pharmaceutical sciences [J Pharm Sci] 1994 Nov; Vol. 83 (11), pp. 1565-8. - Publication Year :
- 1994
-
Abstract
- A novel drug delivery device based on a self-setting bioactive calcium phosphate cement formed from tetracalcium phosphate and dicalcium phosphate has been developed and tested in vitro using the anticancer agent 6-mercaptopurine (6-MP) as a model compound. X-ray diffraction results suggest that equimolar mixtures of the calcium phosphate salts were transformed into hydroxyapatite after being mixed with a dilute phosphoric acid solution, even in the presence of various amounts of 6-MP powder. The inclusion of 6-MP in the reaction mixture resulted in the formation of a homogeneous drug-containing cement. Alternatively, the drug was loaded after cement formation to produce a heterogeneous drug-containing pellet. In vitro drug release from both the homogeneous and heterogeneous drug-loaded cement pellets into simulated body fluid (pH 7.25, 37.0 degrees C) was measured using the rotating-disk method. Release from the homogeneous 5% drug-loaded cements did not obey the Higuchi equation. The release rate from the heterogeneous drug-loaded cements of different thicknesses (1, 2, and 3 mm) was a function of thickness, indicating that release kinetics could be controlled by the design of the cement formulation.
- Subjects :
- Antineoplastic Agents chemistry
Hydroxyapatites
Mercaptopurine chemistry
Polymers
Solubility
X-Ray Diffraction
Antineoplastic Agents administration & dosage
Bone Cements chemistry
Bone and Bones metabolism
Calcium Phosphates chemistry
Drug Delivery Systems
Mercaptopurine administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3549
- Volume :
- 83
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of pharmaceutical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 7891275
- Full Text :
- https://doi.org/10.1002/jps.2600831109