Back to Search
Start Over
Pharmacologic effect of toloxatone on reactivity to the 35% carbon dioxide challenge: a single-blind, random, placebo-controlled study.
- Source :
-
Journal of clinical psychopharmacology [J Clin Psychopharmacol] 1994 Dec; Vol. 14 (6), pp. 414-8. - Publication Year :
- 1994
-
Abstract
- The effect of a short treatment (7 days) with the reversible monoamine oxidase type A inhibitor toloxatone on the reactivity to the inhalation of 35% CO2 was evaluated in 18 panic patients who responded to 35% CO2 inhalation with panic before treatment. A single-blind, placebo-controlled design was applied. Panic patients were randomly assigned to the toloxatone (N = 10) or placebo (N = 8) groups and were given the 35% CO2 challenge on days 1 (before starting the treatment), 3, and 7. Patients on placebo did not report any significant changes in their reactivity to 35% CO2 during the three sessions, whereas patients on toloxatone reported a significant attenuation of the reactivity on day 7. These results indicate that (1) anxiety provoked by the inhalation of 35% CO2 is reproducible; (2) placebo has a negligible effect on 35% CO2 reactivity; and (3) reactivity to 35% CO2 is significantly attenuated by short treatment with toloxatone, possibly related to its antipanic activity.
- Subjects :
- Administration, Inhalation
Administration, Oral
Adult
Agoraphobia drug therapy
Agoraphobia psychology
Antidepressive Agents adverse effects
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Humans
Male
Middle Aged
Oxazoles adverse effects
Panic drug effects
Panic Disorder psychology
Single-Blind Method
Antidepressive Agents therapeutic use
Arousal drug effects
Carbon Dioxide
Oxazoles therapeutic use
Oxazolidinones
Panic Disorder drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0271-0749
- Volume :
- 14
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of clinical psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 7884022