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[Comparative study of the serologic response of IgA and IgM type in the diagnosis of acute toxoplasmosis].

[Comparative study of the serologic response of IgA and IgM type in the diagnosis of acute toxoplasmosis].

Authors :
Lafarga B
Cañas A
Pérez MC
Suárez J
Elcuaz R
Source :
Enfermedades infecciosas y microbiologia clinica [Enferm Infecc Microbiol Clin] 1994 Dec; Vol. 12 (10), pp. 501-4.
Publication Year :
1994

Abstract

Background: IgM serologic response in the diagnosis of acute toxoplasmosis presents interpretation problems. A comparative study with IgA detection of antibodies was performed.<br />Methods: A parallel serologic study was carried out with IgM and IgA enzymoimmunoassay enhancement techniques in the sera of patients suspected of having toxoplasmosis.<br />Results: Positive results for IgM and/or IgA were presented in 74 sera (47 patients): 86.3% for the former and 58.9% for the latter (p < 0.001). The group of IgA-/IgA+ sera presented a low mean of proportionality index (PI): 1.6 versus the IgM+ sera group in the context of IgG seroconversion with a PI of 3.4 (p < 0.001). Out of the 9 patients with demonstrated IgG, all were IgA+ and seven IgM+.<br />Conclusions: The present data seem to support greater specificity of the determination of IgA antibodies than that of IgM in the diagnosis of acute toxoplasmosis.

Details

Language :
Spanish; Castilian
ISSN :
0213-005X
Volume :
12
Issue :
10
Database :
MEDLINE
Journal :
Enfermedades infecciosas y microbiologia clinica
Publication Type :
Academic Journal
Accession number :
7865558