Back to Search
Start Over
A common Ser/Thr polymorphism in the perforin-homologous region of human complement component C7.
- Source :
-
Human heredity [Hum Hered] 1994 Nov-Dec; Vol. 44 (6), pp. 301-4. - Publication Year :
- 1994
-
Abstract
- Complement component C7 plays an important role in the formation of the membrane attack complex of the complement system. Here we describe a novel polymorphism of human C7, namely a nucleotide sequence polymorphism changing codon 367 from AGT (encoding Ser) to ACT (encoding Thr). Using the polymerase chain reaction, the polymorphism is easily detectable either as a MaeIII restriction fragment length polymorphism or by single-strand conformation analysis. The two alleles are both very common, probably in all major races.
- Subjects :
- Base Sequence
Deoxyribonucleases, Type II Site-Specific
Humans
Membrane Glycoproteins genetics
Molecular Sequence Data
Perforin
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single-Stranded Conformational
Pore Forming Cytotoxic Proteins
Serine
Threonine
Complement C7 genetics
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0001-5652
- Volume :
- 44
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Human heredity
- Publication Type :
- Academic Journal
- Accession number :
- 7860081
- Full Text :
- https://doi.org/10.1159/000154235