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[Creutzfeldt-Jakob disease. Report of a case with an unusually long course and immunohistochemical localization of the prion protein and overview of current information].
- Source :
-
Der Nervenarzt [Nervenarzt] 1994 Dec; Vol. 65 (12), pp. 865-73. - Publication Year :
- 1994
-
Abstract
- The human spongiform encephalopathies are a group of neurodegenerative disorders of unknown origin. They comprise a group of horizontally transmissible and genetically determined diseases. We present here a case of Creutzfeldt-Jakob disease with an unusually long clinical course, in which the prion protein was localized immunohistochemically. The generally accepted hypothesis on the pathogenesis of these diseases is the so-called 'prion-hypothesis'. The implications of this hypothesis are discussed and a short review of the literature is given.
- Subjects :
- Atrophy
Basal Ganglia pathology
Cerebral Cortex pathology
Creutzfeldt-Jakob Syndrome diagnosis
Creutzfeldt-Jakob Syndrome genetics
DNA Mutational Analysis
Female
Humans
Middle Aged
Nerve Degeneration genetics
Nerve Degeneration physiology
Neurologic Examination
Neuropsychological Tests
Prions genetics
Brain pathology
Creutzfeldt-Jakob Syndrome pathology
Prions analysis
Subjects
Details
- Language :
- German
- ISSN :
- 0028-2804
- Volume :
- 65
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Der Nervenarzt
- Publication Type :
- Academic Journal
- Accession number :
- 7854509